Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides

Kyle E. Ruhl, Michael J. Di Maso, Harrison B. Rose, Danielle M. Schultz, François Lévesque, Shane T. Grosser, Steven M. Silverman, Shasha Li, Nunzio Sciammetta, Umar Faruk Mansoor

Organic Process Research & Development · 2024 · 10.1021/acs.oprd.4c00165

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★ 5.0 1 rating
5 : Major extension (new functional group) ×1
4 : Minor extension (no new functional group) –
3 : Reproduced as published –
2 : Reproduced with deviation –
1 : Did not work –
– : Extension failed / Inconclusive –

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Industry / CRO chemist
15 Jul 2026
★ 5 : Major extension (new functional group)

Methodology was adapted to a different flow setup, the description was clear and helped in the translation to a different setup.
A different sequence was prepared.