About ChemRepro

Why does this exist?

Anyone who has spent time at a bench knows the frustration: you find a reaction in the literature, set it up carefully, and it simply doesn't work – or works very differently from what was reported. Reproducibility problems in synthetic chemistry are widespread, yet almost never discussed in print. Failed attempts don't get published. Corrections are rare. The knowledge stays locked in lab notebooks and hallway conversations.

ChemRepro exists to change that. It gives practising chemists a place to record what actually happened when they tried a published reaction – honestly, under a chosen display name, and with enough detail to be useful to the next person.

Who is it for?

• Synthetic chemists planning a reaction – check whether others have reproduced the key step before investing lab time.
• Chemists who just attempted a reaction – share your experience and help the community, even if it was a failure.
• Medicinal and process chemists – quickly assess whether a new methodology is reliable enough to build on.
• Students and postdocs – find out what conditions actually work in practice, not just on paper.

How does it work?

1. 1 Paste a DOI into the search bar. ChemRepro fetches the paper's title, authors, and abstract from CrossRef automatically.
2. 2 See ratings from other chemists – how many reproduced it, how many extended it, and their detailed observations.
3. 3 Submit your own rating. No institutional email or registration required. Sign in with ORCID or LinkedIn (coming soon) – both use your provider name by default, with an optional nickname you can set at any time in Settings. Or continue as a guest and pick any display name immediately.

What else can you do?

• › Library – save papers to a personal library, organise them into collections, add private notes, and export references as BibTeX or RIS.
• › Comments & replies – leave threaded comments on any review, like useful contributions, and share individual reviews via link, WhatsApp, email, or LinkedIn.
• › Follow & notify – follow reviewers you trust and subscribe to papers; get in-app notifications when new ratings or comments appear.
• › Private messages – contact other users directly to discuss methodology or share tips.

Integrity & privacy

• ✓ Every rating requires a conflict-of-interest declaration – you cannot rate your own work.
• ✓ One rating per paper per user.
• ✓ Display names only – no institutional affiliation is stored or displayed.
• ✓ ORCID login is optional. Guest login with a chosen display name is always available.

Who runs it?

ChemRepro is an independent project built and maintained by a medicinal chemist based in Basel, Switzerland. It is currently in public beta – features are being added and refined based on feedback from early users.

Questions, suggestions, or bug reports are very welcome: [email protected]

Data API access

ChemRepro curated review data is available via a structured JSON API for vetted researchers, tool developers, and AI applications. The API is not publicly open: access is granted on request after a brief exchange to confirm intended use.

Each record exposes the paper DOI, title, abstract, authors, journal, aggregated reproducibility score, and the full list of community reviews in a format ready for RAG pipelines, fine-tuning datasets, or bibliometric analysis.