Deaminative bromination, chlorination, and iodination of primary amines

Jiang-Hao Xue, Yin Li, Dong-Hang Tan, Fang-Hai Tu, Yuan Liu, Qingjiang Li, Honggen Wang

iScience · 2023 · 10.1016/j.isci.2023.106255

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★ 3.0 1 rating
5 : Major extension (new functional group)
4 : Minor extension (no new functional group)
3 : Reproduced as published ×1
2 : Reproduced with deviation
1 : Did not work
: Extension failed / Inconclusive

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Industry / CRO chemist
16 Jul 2026
★ 3 : Reproduced as published

prepararion of the anomeric amide worked as described, could not extend the scope but still observed traces of product on a very challenging substrate.