Investigation of Parameters that Affect Resin Swelling in Green Solvents

Chidi Amadi‐Kamalu, Holly Clarke, Matthew McRobie, James Mortimer, Michael North, Yanrui Ran, Anne Routledge, Dani Sibbald, Matthew Tickias, Kai Tse, Helen Willway

ChemistryOpen · 2020 · 10.1002/open.202000030

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Abstract

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

★ 5.0 1 rating
5 : Major extension (new functional group) ×1
4 : Minor extension (no new functional group) –
3 : Reproduced as published –
2 : Reproduced with deviation –
1 : Did not work –
– : Extension failed / Inconclusive –

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PhD student
16 Jul 2026
★ 5 : Major extension (new functional group)

The methodology to determine the swelling is well described, it was extended using it to determine the swelling of supported organocatalysts see "Organocatalytic and Halide-Free Synthesis of Glycerol Carbonate under Continuous Flow"

Organocatalytic and Halide-Free Synthesis of Glycerol Carbonate under Continuous Flow

Nicola Zanda, Anna Sobolewska, Esther Alza et al. · ACS Sustainable Chemistry & Engineering · 2021

10.1021/acssuschemeng.1c01060